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Maintenance Phase: Once every two weeks or monthly, depending on how the body responds

Nat Rev Endocrinol 8:2232 Park HS, Huh SH, Kim MS et al (2000) Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation

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These enzymes increase the effectiveness of GSH, and patients with mutations in GST can be at greater risk of suffering from environmental toxins

People with a larger initial decline often notice changes sooner, while mildly deficient individuals may see gentler shifts over a longer period