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It requires conversion to minoxidil sulfate by the enzyme sulfotransferase (SULT1A1) to exert its vasodilatory and hair-growth effects [2]

Neither showed any effect on the primary endpoint, the Clinical Dementia Rating-Sum of Boxes at 104 weeks, nor on secondary cognitive and functional scales, and a pooled analysis found no delay in progression from mild cognitive impairment to dementia (hazard ratio 0.96) [1]

Semaglutide is a GLP-1 receptor agonist, while tirzepatide is a dual GLP-1/GIP receptor agonist