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Following GLP-1 deprescription, patients weight did not significantly increase at 6 or 12 months post deprescription, compared to many well-known drug trials (in red) where patients regain up to two thirds of weight loss after discontinuing the drug

If you're considering stopping or adjusting semaglutide, discussing your genetic predispositions with a qualified healthcare provider can inform safer decision-making

Some users do exactly this

NCT05765643

In the STEP 1 and STEP 3 trials, participants with a mean BMI of 38 showed around 15% weight loss after 68 weeks treatment with 2.4mg semaglutide

The time to plan is now As new uses for GLP-1 medications arise, we believe plan sponsors should start preparing now for increased demand and develop a program approach that balances appropriate access with maintaining benefit affordability