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But the same review makes the important point: human data are extremely limited

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Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

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Monozygotic twin studies, which allow an assessment of the epigenome (gene x environment) independent of underlying genomic sequence mutations, showed high discordance rates and related epigenetic changes [14] in monozygotic twins discordant for psychiatric illnesses