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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
Dose: 2mg twice daily (4mg total) Frequency: Morning and evening Duration: 4-6 weeks maximum Rest period: Equal to cycle length Splitting doses maintains more stable plasma levels throughout the day
Metalloproteinase regulation: It promotes the production of enzymes that break down and remove damaged, disorganized collagen the kind that accumulates with age and UV exposure while simultaneously stimulating the production of new, organized collagen in its place
The problem: very short half-life (~50 minutes) and 3 daily injections at meals , an extremely impractical regimen
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