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To ensure autophagic activation by PFOS, we generated a stable GFP-LC3B clone of RTCs and counted LC3 puncta at 424 h of PFOS treatment (Fig
Macronutrients, bile acids (BAs), and microbiota-derived compounds activate many of these GPCRs expressed by GLP-1 expressing cells ( The main G protein-coupled receptors which activation appears to cause the release of GLP-1 are: GPRC6A (1)
others do not test at all
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This broad receptor activity makes it uniquely valuable as a pharmacological probe for studying the full melanocortin system in preclinical research, while also contributing to its broader side-effect profile
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