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Semaglutide (also known as Wegovy or Ozempic) belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists
However, as this was a review of case reports it does not provide evidence of risk
Dietary modifications, medications, and intestinal transit speed are the most common causes of stool colour variation during GLP-1 therapy
Therefore, the author proposed, could rapid normalization of the cardiometabolic system by GLP-1 RAs be the cause rather than a direct adverse effect of the drug? The commentary adds that further biological plausibility should be considered: GLP-1 receptors are known to be expressed throughout the retina, within retinal ganglion cells, and within the central nervous system, the author wrote
Body composition substudies using dual-energy X-ray absorptiometry (DXA) have shown that while patients lost significant total weight, lean mass decreased proportionally less than fat mass
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