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No significant heterogeneity among studies ( I 2 = 33%, p =0.18), so the fixed-effects model was used to combine the effect sizes

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Because of lack of renal clearance, serum values rose to more than a hundredfold from 422 pmol/L on average to 54 000 pmol/L, with 67 000 pmol/L as highest value, without side-effects

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The FDA grants separate approvals for separate indications, which allows Novo Nordisk to market the same molecule under different names

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