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Delivering a peptide drug orally is challenging because the GI tract degrades proteins

Isso inclui desconforto gastrointestinal, um odor corporal desagradvel (semelhante ao de peixe) e insnia, especialmente se tomada em grandes doses ou antes de dormir

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However, the specific sites that are involved in mediating GLP-1R induced hypophagia are not completely understood

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

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