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Phase 3: Optimization (ongoing) Optimization involves gradual concentration adjustments based on established tolerance and observed results

doi:10.1016/j.placenta.2010.02.011

Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo

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No serious adverse events were reported

The results showed that the proportion of SA--gal positive cells after OGD treatment was significantly higher than that in the control group (Figure 3D)