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In addition, IGF-2, whose expression normally is strictly controlled by parental imprinting is upregulated and functions as an important stimulant of the IGF-1R in cancer (LeRoith and Roberts, 2003)
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PubMed, den Heijer, M., et al
In any case, mounting evidence through germ-free (GF) rodents [80], microbiota transplant studies [81, 82], and microbiota-targeted interventions such as those mediated by dietary supplementation or antibiotics treatment [83, 84] highlight the importance of the gut microbiota composition for adult hippocampal neurogenesis (reviewed in [85])
