going from tirzepatide to semaglutide Switching between weight-loss medications Tirzepatide vs Semaglutide for Microdosing

Discontinuation due to side effects ran at 7% in Phase 2 data, which is lower than Semaglutides 11% discontinuation rate despite Semaglutide having a higher reported nausea incidence at 44%

GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) reduce appetite, slow digestion, and support blood sugar regulation

Moreover, the results demonstrated a significant upregulation of Sqstm1 (P62, which is inversely related to autophagic activity) protein in the HFD group, suggesting that the autophagic process might be hindered [55]

Cutando A, Montero J, Diego RG de, Ferrera MJ, Lopez-Valverde A

For business models, this manifests as high churn

Here's why that's both fantastic and frightening