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Upon entry of Cbl into the cell, a trafficking chaperone named MMACHC facilitates the formation of cob (II)alamin [93, 94]

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Marc LE, James HC, Avrum S

Case example : A patient receives chemotherapy administration (e.g., methotrexate injection) for rheumatologic conditions