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Packer, Witt and Tritschler, 1995 IV ALA achieves plasma concentrations that oral supplementation cannot approach, and its combination with glutathione and NAD+ in a comprehensive longevity protocol produces synergistic antioxidant and metabolic effects that each intervention achieves less effectively in isolation

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Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(/)/Aldh1a1(/) knock-out mice