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GSH is synthesized in the cytosol of all mammalian cells via the two-step reaction shown in the Figure above
Nitrosation and oxidation in the regulation of gene expression
Upregulation of -GCS-HS mRNA in Mucosa from TNBS-Treated Rats To examine if the partial recovery of the mucosal GSH levels observed between 12 weeks after TNBS+ethanol treatment was due to an upregulation of the rate limiting enzyme in the biosynthesis of GSH, we analyzed the -GCS-HS mRNA levels in mucosa from TNBS-treated rats
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