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Additionally, it serves as a coenzyme in several metabolic pathways responsible for energy production, aiding the body to metabolize fats and proteins

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The rationale for B12 inclusion is identical, though semaglutide lacks the GIP receptor component

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However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

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