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These cytokines also contribute to IR through mechanisms including inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway, while also promoting glucocorticoid resistance and HPA axis hyperactivity [80]

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AMPK is central to the regulation of cellular catabolic pathways, thereby inducing FAO and both mitochondrial biogenesis and homeostasis 34,35