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75-LB: CT-388, A novel once-weekly dual GLP-1 and GIP receptor modulator, is safe, well-tolerated, and produces more than 8% weight loss in four weeks in overweight and obese adults
Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery
In educational frameworks, DSIP is positioned at most for the patient with documented, persistent sleep-architecture problems who has genuinely failed sleep hygiene, CBT-I, and melatonin, and who explicitly understands they would be engaging with something investigational rather than a validated treatment
GLP-1 receptor agonists enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which normally raises blood sugar), and slow gastric emptying
doi: 10.1056/NEJMoa2206286 66 BhattDLSzarekMStegPGCannonCPLeiterLAMcGuireDKet al