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What Happens to Appetite When You Stop Many people who have taken GLP-1 medication describe a shift in their relationship with food during treatment a quieting of the mental background noise around eating, a reduced urgency around hunger signals

For people who have struggled to lose weight through diet and exercise, having access to GLP-1s can be really helpful, Phelan said

Semaglutide works by maintaining consistent levels of GLP-1 receptor activation throughout the week, which means injection timing affects how your body responds to hunger and blood sugar signals

Semaglutide is also available as an oral formulation (Rybelsus)

The Annals of Pharmacotherapy

Who May Be a Better Candidate for Each Medication There is no single medication that works best for everyone