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Do not self-inject unless your clinician has taught you sterile technique, proper site selection, and safe needle disposal

While the first injections may provide benefits for a few days, I usually see sustained pain relief over a few weeks after the second injection

Maintenance frequency after that varies depending on how you respond and what your ongoing goals look like

Mandal, P

You've rolled up your sleeve, received your B12 injection, and now you're wondering: how long will it last

The definition of vitamin B12 deficiency varies with the assay used but generally includes serum cobalamin levels below 148 pmol/L plus symptoms, or elevated serum homocysteine, or increased methylmalonic acid (MMA) (74)