Published online July 23, 2024 DOI: 8,877 View 243 Download 4 Web of Science 7 Crossref Abstract PDFPubReader ePub Background Disorders of the blood-brain barrier (BBB) arising from diabetes mellitus are closely related to diabetic encephalopathy
Sep 2006;15(3):237-241
Safety: what we know, what we dont What clinical trial safety reviews suggest The clinical safety review literature reports several reassuring signals: No meaningful increase in IGF-1 in monitored long-term studies (jofem.org) No clear negative effect on carbohydrate metabolism in testing described (contrast with full hGH) (jofem.org) No clear immunogenicity signal (e.g., anti-AOD antibodies) in the subset assessed in those trials (jofem.org) The major limitation: long-term real-world certainty is thin The problem with many peptides is not that everything is dangerousits that the certainty level is often lower than patients assume
mibavademab, a leptin receptor agonist (NCT06373146)
An antioxidant that supports metabolism and healthy nerves
The primary outcome of this study was the first diagnosis of CRC within 15 years from the initial treatment of GLP-1RAs or non-GLP-1RA diabetes medications (insulin, metformin, alpha-glucosidase inhibitors, dipeptidyl-peptidase-4 inhibitors (DPP-4i), sodium-glucose cotransporter-2 inhibitors (SGLT2i), sulfonylureas (SU), and thiazolidinediones (TZD))