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Signs and symptoms of bleeding related to thrombocytopenia can include: Easy bleeding or bruising Pinpoint hemorrhages into the skin or lining of the mouth (petechiae) or bruising (purpura) Nosebleeds Bleeding gums Heavy menstrual periods Blood in the stool or urine Other signs and symptoms that may occur in people with thrombocytopenia can include: Enlargement of the spleen (splenomegaly) Fatigue Jaundice (yellowing of the skin and whites of the eyes) What Are Common Causes of Low Platelet Counts