semaglutide chinese drugmakers developing generic drugs of Novo Nordisk's Ozempic Chinese version of Novo Nordisk

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Nat Rev Drug Disco

Liraglutide was developed earlier and has a shorter half-life of approximately 13 hours, requiring daily dosing

However, the FDA declared the semaglutide shortage resolved in February 2025, and compounded versions are no longer legally available as of May 2025

Others prefer a brief washout to assess how their body responds before restarting on a new formulation or compound

It is crucial that prescribing clinicians review: Current thyroid function tests (TSH, free T4, free T3) Cardiovascular status and any history of arrhythmias Renal function, particularly if there are concerns about dehydration Pre-existing diabetic retinopathy, which requires close monitoring Concurrent medications and potential drug interactions Patient's ability to recognise and report symptoms of thyroid dysfunction or medication side effects Important considerations before starting Mounjaro include: Pregnancy planning: Mounjaro is not recommended during pregnancy and should be discontinued at least 1 month before a planned pregnancy Oral contraceptive effectiveness may be reduced