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The FDA approved semaglutide for chronic weight management in adults with obesity (BMI 30+) or overweight (BMI 27+) with at least one weight-related condition like hypertension, high cholesterol, or type 2 diabetes

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The last one, CK-BB, is found in the brain

Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes