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Future studies stratifying patients by precise etiological subgroups and assessing site-specific bone outcomes will be crucial to determine the role of GM in the OP pathogenesis with different etiological contexts

Thus, studies on the combination of strategies that can penetrate a normal BBB or on the dynamics of BBB disruption, as well as on the identification of biomarkers of brain vascular injury, might pave the way to new drug delivery approaches targeting BBB in the near future

The appropriate route and dose depend on the clinical scenario

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