Great I am finishing my first month of these injections and I have lost 4 lbs so far
Pros: Naturally occurring in the body, giving it a favorable long-term safety profile compared to many synthetic peptides Backed by decades of published research on collagen synthesis, wound healing, and antioxidant activity Available in both topical (cosmetic-legal) and injectable forms depending on desired intensity Cons: Injectable/research-grade product is not standardized or quality-controlled the way pharmaceuticals are, so purity varies significantly by vendor High topical concentrations can cause skin irritation, and there is limited long-term human trial data for injectable use Side Effects: Topical use is generally well tolerated, with occasional mild redness, tingling, or dryness at the application site
Most protocols suggest administration first thing in the morning on an empty stomach and again before bed
NNMT expression is significantly upregulated in white adipose tissue during obesity (3-5 fold) and increases with age across multiple tissues, creating a metabolic drain on both the NAD+ pool and the methylation budget
Local injection (near the injury site) delivers maximum concentrations directly to damaged tissue
It's frustrating, demotivating and it might leave you wondering if there's something more than just calories at play