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However, supplementation has become a popular method for boosting levels

And the doctor who prescribed it would refute the lack of data, saying the absence of evidence is not evidence of absence, and that his patients are deriving substantial benefit without side effects

Synthetic peptides can be altered to persist longer in blood or to target specific tissues by attaching small chemical moieties or cyclizing the chain to prevent degradation

The catch is that the effect requires consistent, high-dose exposure, fades when treatment stops, and works very unevenly between individuals

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This makes it potentially valuable for neuropathic pain conditions