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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
Methods We used a combination of glucagon secretion measurements in mouse and human islets (including islets from donors with type 2 diabetes), total internal reflection fluorescence microscopy imaging of secretory granule dynamics, recordings of cytoplasmic Ca 2+ and measurements of protein kinase A activity, immunocytochemistry, in vivo physiology and GTP-binding protein dissociation studies to explore how GLP-1 exerts its inhibitory effect on glucagon secretion and the role of the metabolite GLP-1(936)
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The company focuses on discovery and development of translational medicine for metabolic and immune-related diseases
High-purity research peptides, with HPLC verification and a per-batch COA
