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As a GLP-1 receptor agonist, semaglutide binds to GLP-1 receptors in the brain, particularly in areas controlling appetite such as the hypothalamus
It activates the GLP-1 receptor along with two others the GIP receptor and the glucagon receptor
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Orforglipron (LY3502970), a novel, oral nonpeptide glucagonlike peptide1 receptor agonist: a Phase 1a, blinded, placebocontrolled, randomized, singleand multipleascendingdose study in healthy participants
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