Dosing in combination animal studies typically used ranges similar to monotherapy for each agent
Here is my clinical translation: Do not stop GLP-1 medications out of fear of muscle wasting
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Clinically, GLP-1s are generally safe when prescribed and monitored properly, but they can cause side effects such as nausea, vomiting, and gastrointestinal discomfort, especially when people first start treatment
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Decisions regarding treatment modification should always be made in consultation with the prescribing clinician, considering the overall benefit-risk profile, treatment objectives, and individual patient circumstances