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Advantage: Potential for higher bioavailability than standard oral ingestion Challenge: Peptides are poorly absorbed through intact mucosal membranes without transport mechanisms Evidence: No studies confirm enhanced sublingual bioavailability for Dihexa Standard oral (swallowed): Tablets swallowed with water, absorbed through the gastrointestinal tract

However, mild side effects such as digestive upset, nausea, and occasional skin reactions may occur, especially when beginning supplementation

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doi:10.1136/gut.2003.037747 Talebi S, Karimifar M, Heidari Z, Mohammadi H, Askari G

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