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NAD+ plays a vital role in redox reactions and sirtuin activation
However, the medication's gastrointestinal effectsparticularly nausea, vomiting, and diarrheacan lead to dehydration and prerenal acute kidney injury if fluid intake is inadequate
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Clin Pharmacol Ther 31:151156 Miners JO, Penhall R, Robson RA, Birkett DJ (1988) Comparison of paracetamol metabolism in young adult and elderly males
It protects DNA
Unlike ibuprofen, acetaminophen's mechanism of action does not depend on prostaglandin inhibition, so it works effectively even with delayed gastric emptying
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