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Indole-3-carbinol (I3C) and its metabolite DIM exert hormone-modulatory effects by shifting estrogen metabolism from the genotoxic 16-hydroxyestrone pathway toward the less carcinogenic 2-hydroxyestrone pathway, enhancing CYP1A1/1A2 activity, and simultaneously downregulating ER and upregulating ER expression, which together lead to suppression of estrogen-driven proliferation and sensitization of tumours to endocrine therapies (191)
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Acupoint stimulation therapy is shown to improve palpitations, dyspnea, cognitive impairment, anxiety, depression, and other symptoms in PASC patients 765
What the evidence supports The peer-reviewed literature on MIC-B12 addresses several mechanisms relevant to longevity and wellness including methylation, B12 metabolism, and lipid utilization
Through these mechanisms, UAE researchers believe that Epithalon can contribute to improved cellular health, potentially slowing down the aging process and promoting longevity
