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This highlights the importance of having a targeted treatment approach and exercising caution when using GLP-1 RAs in older populations

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Many patients walk in and say "I want to lose weight." The doctor hears a cosmetic concern

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Indeed, the experience of several randomized control trials has been included in the most recent guidelines ( In patients with T2DM, the treatment with SGLT2-i has been associated with a reduction in hospitalization for heart failure and cardiovascular deaths, regardless of pre-existing cardiovascular disease ( Several studies ( This heterogeneity in CV benefits across the trials, also among studies in which drugs of the same class have been used, could be explained by different study designs (i.e

NSAIDs cause the kidneys to retain sodium and water, increasing blood volume and placing extra strain on the heart