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A few signs that it might be time to reach out include: persistent or worsening nausea that doesnt improve over time frequent vomiting or trouble keeping food and fluids down signs of dehydration, like dizziness, dry mouth, or dark urine severe stomach pain or discomfort In some cases, your doctor might recommend adjusting your dose, slowing down titration, or switching medications

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By 2050, the burden of stroke in individuals (aged 65 years) will increase significantly: 104.7% in incidence, 218.5% in prevalence, 100.0% in mortality, and 58.9% in DALYs (54)