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The affected enzymes, ERK1/2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, are believed to play significant roles in cell growth, migration, and angiogenesis, which is the development of new blood vessels

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Ann Neurol 52:771778 Klivenyi P, Kiaei M, Gardian G et al (2004) Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis

Relationship-based models often engage parents and focus on fostering genuine relationships and creating a desire and ability to live in a changing environment

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Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, et al