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This tripeptide was first identified in human plasma in the 1970s

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Semin Pediatr Neurol (2013) 20(3):18893.10.1016/j.spen.2013.09.002 31 DongXGuanXChenKJinSWangCYanLet alAbnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine