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The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others
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It is usually paired with food and stress work, since those inputs still drive the flare
[PubMed ID: 21747763]
Start by taking a low dose for a few weeks, and then gradually increase it while maintaining a high fluid intake
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