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7 The formalin test has rapidly become the most widely used preclinical screening test, and annual publications still show a positive trend

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MRI may show cerebral white matter atrophy, ventricular enlargement, periventricular gliosis, optic nerve atrophy, delayed myelin formation or dysplasia, cerebellar hypoplasia, cerebellar hemisphere atrophy, and hypersignal in the subcortical white matter [116, 117]

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