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Although the use of exosomes as a delivery system has its drawback (for example, quickly eliminating by the reticuloendothelial system, lack of efficient encapsulation methods, and potential immune responses), exosomes targeted at tumors may allow systemic administration of miRNA as cancer treatment and are thus worthy of attention

Such a response has been proposed to contribute to oxidative stress and persistent white matter damage that follow perinatal hypoxia

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For example, some TACs as NKA and its receptor increased by stimulus of IFN- concomitantly with AHR in murine models of severe asthma (asthma resistant to classical treatment) (Kobayashi et al., 2012), even this bronchonconstrictor effect is similar to the induced by ACh in guinea pigs (Grassin-Delyle et al., 2010)