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For insulin pens, dose accuracy, injection depth consistency, and needle gauge refinements have incremental clinical value that is real, if modest

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If your unopened pen has been left unrefrigerated, this represents a deviation from recommended storage conditions that may compromise the medication's stability and efficacy

The lipofuscin is found in histiocytes or macrophages and is thought to represent degradation products from cells undergoing apoptosis

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Supplementary material The Supplementary Material for this article can be found online at: Supplementary Figure 1 Funnel plot to assess publication bias