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This indicates that SAHA promotes ubiquitination and clearance of damaged mitochondria via the PINK1-Parkin axis, thereby suppressing tumor growth ( in vivo studies confirm that oral administration of 4SC-202 significantly inhibits tumor growth and reduces PRLR pathway activity within the tumor tissue, with no observed significant hepatotoxicity or organ pathological damage, highlighting its excellent in vivo safety profile ( 4.8 Colorectal cancer Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, with its incidence and mortality rates gradually increasing in recent years

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Oral delivery changes the absorption kinetics and can affect how GI side effects manifest

doi: 10.1038/s43016-024-01095-7, 124 RheaE