Bird RG, Draper CC, Ellis DS (1972) A cytoplasmic polyhedrosis virus in midgut cells of Anopheles stephensi and in the sporogonic stages of Plasmodium berghei yoelii
36 As 85% of aconitase in the brain is the mitochondrial isozyme, a decrease in brain aconitase activity is considered a sensitive indicator of excess mitochondrial superoxide production
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FOXO4-DRI vs nearby senolytics Option FOXO4-DRI Type D-retro-inverso peptide Human trial stage None (preclinical only) Option Dasatinib + Quercetin (D+Q) Type Small-molecule drug + flavonoid Human trial stage Early human trials (e.g., Alzheimer's) Option Navitoclax Type BCL-2 family inhibitor Human trial stage Later-stage trials (e.g., myelofibrosis) D+Q and navitoclax are further along in humans but can affect healthy cells (e.g., low platelets)
Plus, their small size allows them to cross biological barriers like the placental and blood-brain barriers
Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock