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MRL/lpr mice A mouse strain with an Fs gene mutation (lpr) leading to defective lymphocyte apoptosis and lupus-like symptoms

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And absent more rigorous studies, the team warned, it will remain difficult to convince the broader medical community that this so-called wonderful compound meets the criteria of a legitimate therapeutic agent. But it turns out, one group had begun to give it a go anyway

Starting with lower doses and gradually increasing lets you assess how well you tolerate it

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Inhibition of the glutamate-cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells