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Journal of Functional Foods 15, 2334 (2015)

Quick Answer: Yes, glutathione can cause skin rashes in some individuals, typically as a result of an allergic reaction or a temporary sensitivity during the detoxification process

Patrignani P, Panara MR, Tacconelli S, Seta F, Bucciarelli T, Ciabattoni G et al

No effect was observed on NLRP3 activation

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How Glutathione IV Therapy Enhances Detoxification Glutathione IV therapy delivers a high dose of glutathione directly into the bloodstream, bypassing the digestive system for maximum absorption