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Staresinic M, Sebecic B, Patrlj L, et al

We next introduced a quadruple mutation into c-MET-IPT1 (R592E/N593E/K595E/K599E), which was designed to fully disrupt the interaction between heparin and c-MET

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Cagrilintide is a 39amino-acid peptide with structural modifications (including an N-terminal fatty diacid chain) designed to improve stability and reduce fibril formation compared with native amylin