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4.7 Vascular niche and endothelial cell signaling In addition to angiogenesis, endothelial cells play an important role in the regulation of breast cancer progression by forming a vascular niche which promotes the survival, stemness, and metastatic spread of tumor cells (127)

doi: 10.3390/ijms22126574 57 Delgado-RocheL.MestaF

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Rare cases of allergic contact dermatitis have been described with prolonged copper exposure, so persistent or worsening inflammation should prompt discontinuation and medical evaluation

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