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However, if frozen for more than two months the liposome integrity may be damaged

When TDP-43 is mislocalized from the nucleus to the cytoplasm, there is both loss of nuclear function and toxic sequestration of proteins and ribonucleic acids (RNAs) within the aggregates

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That usually means documenting the reconstitution solvent used, keeping records at the lot level, minimizing repeated handling, and storing material under conditions consistent with the vendors instructions and the labs SOPs