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[57] It achieves this by activating the AMPK and SIRT1 pathways, which in turn upregulates the expression of uncoupling protein 1 (UCP1)

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Mechanism of action: melanocortin cAMP/PKA/MITF cascade Presynaptic activation of cutaneous MC1R and central MC3R/MC4R/MC5R PRIMARY PATHWAY MELANOGENESIS MC1R on melanocytes High-affinity binding to the MC1R receptor on epidermal melanocytes

It became the first dual GLP-1 and GIP receptor agonist indicated for T2D [4, 5]

Sixth, it supports dermal papilla cells, the specialized cells at the base of the follicle that are essential for hair formation and cycling