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However, despite these advantages, the clinical use of native GLP-1 is significantly limited by its short plasma half-life (12 min), owing to rapid enzymatic degradation by DPP-4 and renal clearance
In: Bolton AJM, editor
McMahon, H
Doses are reached through gradual escalation to limit side effects
Food and Drug Administration (FDA) approved oral semaglutide in September 2019 for use in adults with type 2 diabetes
A cofactor is a mineral, vitamin, or nutrient that is needed in order for an enzyme to work properly
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